Dystonia as the major manifestation of Leigh's syndrome
Identifieur interne : 005B89 ( Main/Exploration ); précédent : 005B88; suivant : 005B90Dystonia as the major manifestation of Leigh's syndrome
Auteurs : Gabriel Lera [Royaume-Uni] ; Kailash Bhatia [Royaume-Uni] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
- Adolescent, Adult, Basal Ganglia (pathology), Basal ganglia, Basal ganglion, Biopsy, Case study, Child, Computerized axial tomography, DNA Mutational Analysis, DNA, Mitochondrial (genetics), Diagnosis, Differential, Dystonia, Dystonia (diagnosis), Dystonia (etiology), Dystonia (pathology), Exploration, Female, Humans, Leigh Disease (complications), Leigh Disease (diagnosis), Leigh Disease (pathology), Leigh disease, Leigh's syndrome, Magnetic Resonance Imaging, Male, Muscles (pathology), Neurologic Examination, Nuclear magnetic resonance imaging.
- MESH :
- chemical , genetics : DNA, Mitochondrial.
- complications : Leigh Disease.
- diagnosis : Dystonia, Leigh Disease.
- etiology : Dystonia.
- pathology : Basal Ganglia, Dystonia, Leigh Disease, Muscles.
- Adolescent, Adult, Biopsy, Child, DNA Mutational Analysis, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Neurologic Examination.
Abstract
We report eight patients who had a progressive illness dominated by generalised dystonia and who had clinical and imaging features suggestive of Leigh's syndrome (LS). Six of the eight cases were male. Early development was usually normal but three cases exhibited impaired mental and/or motor development, and three others had a history of an earlier unexplained encephalopathy or febrile illness. The onset of the dystonia occurred at a mean age of 3 years (range 2 months‐7 years). All had abnormalities in the basal ganglia on brain imaging; symmetrical bilateral lucencies or calcification were seen in the basal ganglia on computed tomography scan in five cases, and high signal lesions were evident in these regions on T2‐weighted magnetic resonance imaging sequences in seven cases. Other causes of such changes in the basal ganglia were excluded by appropriate investigations. Raised blood lactate levels were found in four of the eight patients. Muscle biopsies were done in seven patients but histology and histochemistry were normal. The common mitochondrial DNA mutations associated with LS in mitochondrial encephalopathies were not found in the six cases examined. LS presenting as a pure dystonic syndrome is uncommon, but should be considered in the differential diagnosis of symptomatic dystonia presenting in childhood.
Url:
DOI: 10.1002/mds.870090610
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="642">642</biblScope><biblScope unit="page" to="649">649</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">30681D67B0885102479B0380DFED72DE7288F747</idno><idno type="DOI">10.1002/mds.870090610</idno><idno type="ArticleID">MDS870090610</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Basal Ganglia (pathology)</term><term>Basal ganglia</term><term>Basal ganglion</term><term>Biopsy</term><term>Case study</term><term>Child</term><term>Computerized axial tomography</term><term>DNA Mutational Analysis</term><term>DNA, Mitochondrial (genetics)</term><term>Diagnosis, Differential</term><term>Dystonia</term><term>Dystonia (diagnosis)</term><term>Dystonia (etiology)</term><term>Dystonia (pathology)</term><term>Exploration</term><term>Female</term><term>Humans</term><term>Leigh Disease (complications)</term><term>Leigh Disease (diagnosis)</term><term>Leigh Disease (pathology)</term><term>Leigh disease</term><term>Leigh's syndrome</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Muscles (pathology)</term><term>Neurologic Examination</term><term>Nuclear magnetic resonance imaging</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Mitochondrial</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Leigh Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonia</term><term>Leigh Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term><term>Dystonia</term><term>Leigh Disease</term><term>Muscles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Biopsy</term><term>Child</term><term>DNA Mutational Analysis</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Neurologic Examination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Encéphalomyélopathie nécrosante subaiguë Leigh</term><term>Enfant</term><term>Etude cas</term><term>Exploration</term><term>Imagerie RMN</term><term>Noyau gris central</term><term>Tomodensitométrie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report eight patients who had a progressive illness dominated by generalised dystonia and who had clinical and imaging features suggestive of Leigh's syndrome (LS). Six of the eight cases were male. Early development was usually normal but three cases exhibited impaired mental and/or motor development, and three others had a history of an earlier unexplained encephalopathy or febrile illness. The onset of the dystonia occurred at a mean age of 3 years (range 2 months‐7 years). All had abnormalities in the basal ganglia on brain imaging; symmetrical bilateral lucencies or calcification were seen in the basal ganglia on computed tomography scan in five cases, and high signal lesions were evident in these regions on T2‐weighted magnetic resonance imaging sequences in seven cases. Other causes of such changes in the basal ganglia were excluded by appropriate investigations. Raised blood lactate levels were found in four of the eight patients. Muscle biopsies were done in seven patients but histology and histochemistry were normal. The common mitochondrial DNA mutations associated with LS in mitochondrial encephalopathies were not found in the six cases examined. LS presenting as a pure dystonic syndrome is uncommon, but should be considered in the differential diagnosis of symptomatic dystonia presenting in childhood.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lera, Gabriel" sort="Lera, Gabriel" uniqKey="Lera G" first="Gabriel" last="Lera">Gabriel Lera</name></region><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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